Regulation of subtelomeric silencing during stress response.
Identifieur interne : 001970 ( Main/Exploration ); précédent : 001969; suivant : 001971Regulation of subtelomeric silencing during stress response.
Auteurs : Wandong Ai [États-Unis] ; Paula G. Bertram ; Chi Kwan Tsang ; Ting Fung Chan ; X F Steven ZhengSource :
- Molecular cell [ 1097-2765 ] ; 2002.
Descripteurs français
- KwdFr :
- Chromatine (génétique), Extinction de l'expression des gènes (physiologie), Gènes fongiques (MeSH), Mitogen-Activated Protein Kinases (métabolisme), Phosphorylation (MeSH), Protéines SIR de Saccharomyces cerevisiae (physiologie), RT-PCR (MeSH), Régulation de l'expression des gènes fongiques (MeSH), Saccharomyces cerevisiae (effets des médicaments et des substances chimiques), Saccharomyces cerevisiae (génétique), Saccharomyces cerevisiae (physiologie), Sirolimus (pharmacologie), Télomère (génétique).
- MESH :
- effets des médicaments et des substances chimiques : Saccharomyces cerevisiae.
- génétique : Chromatine, Saccharomyces cerevisiae, Télomère.
- métabolisme : Mitogen-Activated Protein Kinases.
- pharmacologie : Sirolimus.
- physiologie : Extinction de l'expression des gènes, Protéines SIR de Saccharomyces cerevisiae, Saccharomyces cerevisiae.
- Gènes fongiques, Phosphorylation, RT-PCR, Régulation de l'expression des gènes fongiques.
English descriptors
- KwdEn :
- Chromatin (genetics), Gene Expression Regulation, Fungal (MeSH), Gene Silencing (physiology), Genes, Fungal (MeSH), Mitogen-Activated Protein Kinases (metabolism), Phosphorylation (MeSH), Reverse Transcriptase Polymerase Chain Reaction (MeSH), Saccharomyces cerevisiae (drug effects), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (physiology), Silent Information Regulator Proteins, Saccharomyces cerevisiae (physiology), Sirolimus (pharmacology), Telomere (genetics).
- MESH :
- chemical , genetics : Chromatin.
- chemical , metabolism : Mitogen-Activated Protein Kinases.
- drug effects : Saccharomyces cerevisiae.
- genetics : Saccharomyces cerevisiae, Telomere.
- chemical , pharmacology : Sirolimus.
- physiology : Gene Silencing, Saccharomyces cerevisiae, Silent Information Regulator Proteins, Saccharomyces cerevisiae.
- Gene Expression Regulation, Fungal, Genes, Fungal, Phosphorylation, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Sir proteins play a critical role in silent chromatin domains. While mutations can cause derepression of heterochromatin, it remains unclear whether silencing is actively involved in transcriptional control under changing environmental conditions. We find that TOR inhibits Sir3 phosphorylation. Rapamycin or stress induced by chlorpromazine leads to activation of MAP kinase Mpk1/Slt2, which phosphorylates Sir3. Sir3 hyperphosphorylation is correlated with reduced subtelomeric silencing, increased subtelomeric cell wall gene expression, and stress resistance to chlorpromazine, but does not affect the silent HML and rDNA loci. Based on these observations, we propose that regulation of silencing may be used to control gene expression at specific silent chromatin domains in response to stress and possibly other environmental changes.
DOI: 10.1016/s1097-2765(02)00695-0
PubMed: 12504006
Affiliations:
- États-Unis
- Missouri (État)
- Saint-Louis (Missouri)
- École de médecine (Université Washington de Saint-Louis)
Links toward previous steps (curation, corpus...)
Le document en format XML
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Bertram</name></author><author><name sortKey="Tsang, Chi Kwan" sort="Tsang, Chi Kwan" uniqKey="Tsang C" first="Chi Kwan" last="Tsang">Chi Kwan Tsang</name></author><author><name sortKey="Chan, Ting Fung" sort="Chan, Ting Fung" uniqKey="Chan T" first="Ting Fung" last="Chan">Ting Fung Chan</name></author><author><name sortKey="Zheng, X F Steven" sort="Zheng, X F Steven" uniqKey="Zheng X" first="X F Steven" last="Zheng">X F Steven Zheng</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2002">2002</date><idno type="RBID">pubmed:12504006</idno><idno type="pmid">12504006</idno><idno type="doi">10.1016/s1097-2765(02)00695-0</idno><idno type="wicri:Area/Main/Corpus">001955</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001955</idno><idno type="wicri:Area/Main/Curation">001955</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001955</idno><idno type="wicri:Area/Main/Exploration">001955</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Regulation of subtelomeric silencing during stress response.</title><author><name sortKey="Ai, Wandong" sort="Ai, Wandong" uniqKey="Ai W" first="Wandong" last="Ai">Wandong Ai</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology and Immunology, Washington University School of Medicine, 63110, St. Louis, MO 63110, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Immunology, Washington University School of Medicine, 63110, St. Louis, MO 63110</wicri:regionArea><placeName><region type="state">Missouri (État)</region><settlement type="city">Saint-Louis (Missouri)</settlement></placeName><orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName></affiliation></author><author><name sortKey="Bertram, Paula G" sort="Bertram, Paula G" uniqKey="Bertram P" first="Paula G" last="Bertram">Paula G. 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While mutations can cause derepression of heterochromatin, it remains unclear whether silencing is actively involved in transcriptional control under changing environmental conditions. We find that TOR inhibits Sir3 phosphorylation. Rapamycin or stress induced by chlorpromazine leads to activation of MAP kinase Mpk1/Slt2, which phosphorylates Sir3. Sir3 hyperphosphorylation is correlated with reduced subtelomeric silencing, increased subtelomeric cell wall gene expression, and stress resistance to chlorpromazine, but does not affect the silent HML and rDNA loci. Based on these observations, we propose that regulation of silencing may be used to control gene expression at specific silent chromatin domains in response to stress and possibly other environmental changes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12504006</PMID><DateCompleted><Year>2003</Year><Month>03</Month><Day>21</Day></DateCompleted><DateRevised><Year>2019</Year><Month>09</Month><Day>16</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1097-2765</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><Issue>6</Issue><PubDate><Year>2002</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Molecular cell</Title><ISOAbbreviation>Mol Cell</ISOAbbreviation></Journal><ArticleTitle>Regulation of subtelomeric silencing during stress response.</ArticleTitle><Pagination><MedlinePgn>1295-305</MedlinePgn></Pagination><Abstract><AbstractText>Sir proteins play a critical role in silent chromatin domains. While mutations can cause derepression of heterochromatin, it remains unclear whether silencing is actively involved in transcriptional control under changing environmental conditions. We find that TOR inhibits Sir3 phosphorylation. Rapamycin or stress induced by chlorpromazine leads to activation of MAP kinase Mpk1/Slt2, which phosphorylates Sir3. Sir3 hyperphosphorylation is correlated with reduced subtelomeric silencing, increased subtelomeric cell wall gene expression, and stress resistance to chlorpromazine, but does not affect the silent HML and rDNA loci. 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Steven</ForeName><Initials>XF</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mol Cell</MedlineTA><NlmUniqueID>9802571</NlmUniqueID><ISSNLinking>1097-2765</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002843">Chromatin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C084122">SIR3 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D038281">Silent Information Regulator Proteins, Saccharomyces cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber><NameOfSubstance UI="D020928">Mitogen-Activated Protein 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MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D038281" MajorTopicYN="N">Silent Information Regulator Proteins, Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000494" 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IdType="doi">10.1016/s1097-2765(02)00695-0</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Missouri (État)</li></region><settlement><li>Saint-Louis (Missouri)</li></settlement><orgName><li>École de médecine (Université Washington de Saint-Louis)</li></orgName></list><tree><noCountry><name sortKey="Bertram, Paula G" sort="Bertram, Paula G" uniqKey="Bertram P" first="Paula G" last="Bertram">Paula G. Bertram</name><name sortKey="Chan, Ting Fung" sort="Chan, Ting Fung" uniqKey="Chan T" first="Ting Fung" last="Chan">Ting Fung Chan</name><name sortKey="Tsang, Chi Kwan" sort="Tsang, Chi Kwan" uniqKey="Tsang C" first="Chi Kwan" last="Tsang">Chi Kwan Tsang</name><name sortKey="Zheng, X F Steven" sort="Zheng, X F Steven" uniqKey="Zheng X" first="X F Steven" last="Zheng">X F Steven Zheng</name></noCountry><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Ai, Wandong" sort="Ai, Wandong" uniqKey="Ai W" first="Wandong" last="Ai">Wandong Ai</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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